The study, published in the journal Environmental Health Perspectives, showed that these drugs could affect the fertility of unborn children.
Think twice before taking painkillers during pregnancy, as researchers have found that they can affect the fertility of the fetus later. The study, published in the journal Environmental Health Perspectives, showed that these drugs could affect the fertility of unborn children.
You can also influence the fertility of future generations by leaving their mark on the DNA, the study adds, leading to growing evidence that some medications, including acetaminophen, must be used with caution during pregnancy.
“We encourage women to think carefully before taking painkillers during pregnancy and following existing guidelines by taking the lowest possible dose as soon as possible,” said lead researcher Rod Mitchell of the University of Toronto. Edinburgh.
The researchers analyzed the effects of acetaminophen and ibuprofen on human testicles and ovaries.
They found similar effects using a variety of experimental approaches, including laboratory tests on human tissue specimens and animal studies.
Human tissues exposed to any of the drugs on a plate for one week had a reduced number of cells resulting in sperm and eggs termed germ cells, according to the study.
Ovaries exposed to paracetamol for one week contained more than 40% fewer egg-producing cells. After exposure to ibuprofen, the number of cells was reduced by almost half.
Experts say it is important because girls produce all their eggs in the uterus, if they were born with a small number, could lead to early menopause.
Exposure to analgesics during development may also affect unborn children, according to the study.
The testicular tissue exposed to analgesics in a culture dish had approximately one fourth fewer sperm-forming cells after exposure to paracetamol or ibuprofen.
Previous studies in rats have shown that analgesics administered during pregnancy result in a reduction of germ cells in female offspring. This affected their fertility and fertility of women in later generations.
Scientists have discovered that exposure to paracetamol or ibuprofen induces mechanisms in the cell that cause changes in the structure of DNA called epigenetic markers.
These traits can be inherited, which explains how the effects of analgesics on fertility can be transferred to future generations.
According to the researchers, the effects of analgesics on germ cells are caused by their effect on molecules called prostaglandins that have key functions in the ovaries and testes.